There is no specific rule. For example if one has bowel disorders then it might be best to start with the bowel program. In her first books, Dr. Clark recommended to start with the parasite cleanse, followed by the kidney and then the liver cleanse and then the bowel program. However in more recent books, she would have her patients start with the kidney cleanse and clear out their hepatic bacteria by taking the liver tea first before the parasite cleanse.